Engineering the genetics of wild insect populations with synthetic selfish genetic elements, to fight human disease. Mosquitoes and ticks are essential vectors for major human diseases such as dengue, yellow fever, malaria and Lyme disease. An attractive approach to suppressing these diseases involves replacing the wild pest population with modified counterparts unable to transmit disease (population replacement). An essential component of such a strategy involves the use of a genetic drive mechanism able to promote the spread of genes conferring disease resistance, even if their presence carries a fitness cost. We have developed a synthetic selfish genetic element (Medea) that is able to drive population replacement in Drosophila (Chen et al., (2007) A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Science. 316: 597-600).

Postdoctoral positions are available to develop and characterize Medea elements in mosquitoes and other organisms at the molecular, genetic and population levels. We are also interested in the development of novel selfish genetic elements able to bring about local population suppression or elimination, as well as methods for engineering reproductive isolation. Population genetic engineering is an exciting new research area with many opportunities. Postdoctoral candidates should hold recent Ph.D. and/or M.D. degrees.

We (http://www.its.caltech.edu/~haylab/) are an energetic and well-funded team with modern lab space located in sunny Pasadena. We seek to expand our group with the addition of highly motivated candidates with experience in molecular and population genetics, cell biology, developmental biology and modeling. Candidates with experience in mosquito husbandry and transformation are encouraged to apply, though this experience is not essential. Close interactions with other labs at Caltech and in the Southern California area (UCLA, UC Irvine, UC Riverside) make the environment collegial and stimulating.

Contact:
Bruce A. Hay
Associate Professor
Division of Biology, MC 156-29
California Institute of Technology
1200 East California Boulevard
Pasadena, CA 91125
haybruce@caltech.edu

___________________________________________________________________

Ad to be printed on Work@UH and in Science (and other national periodicals)

Associate or Full Professor (Virologist), I/M 4-5, position number 84143, John A. Burns School of Medicine (Kaka‘ako Campus), tenure-track, 11-month, 100% full-time, general funds, annually renewable depending on funding and performance, to begin approximately March 2008, pending position clearance and availability of funds.  Departmental appointment will be determined by the candidate’s qualifications; therefore, the candidate may be appointed to a clinical or basic science department.  Duties: The Asia-Pacific Institute of Tropical Medicine and Infectious Diseases (APITMID, http://apitmid.hawaii.edu) is seeking a Virologist to establish an independent, transdisciplinary and translational research program of excellence on BSL-2 and BSL-3 vector-borne viruses causing hemorrhagic fevers or meningoencephalitis.  The successful applicant will also engage in collaborative studies on microbe-host interactions with other university faculty, and contribute actively to the graduate training and medical education programs, involving traditional lectures and problem-based learning (PBL) tutoring, within the medical school. Minimum qualifications: Associate Professor: M.D., M.D./Ph.D., Ph.D., D.V.M., or other doctoral degree in the biosciences, with at least four years of experience as an Assistant Professor, research funding from federal or private sources and a strong publication record in vector-borne infectious diseases; proven ability in teaching and recognition for significant scholarly contributions. If M.D., must be board eligible or certified and eligible for Hawaii medical license.  Full Professor: Same as Associate Professor, with at least four years of experience as an Associate Professor, with a strong record of recent high-impact publications and active NIH funding. Desirable qualifications: Research: Demonstrated laboratory and field research experience in vector-borne viral diseases, including pathogenesis, viral diagnostics, and cellular and/or animal models of virus-host interactions, as well as expertise in classical and molecular virology and experience in BSL-3 laboratory management. Sustained extramural funding record. Teaching: Experience in PBL pedagogy. Administration: Experience as departmental chair.  Pay range: Commensurate with qualifications and experience.  To apply: Interested candidates should submit a cover letter indicating how they satisfy the minimum and desirable qualifications, official transcripts, names and contact information (including e-mail addresses) of five professional references, current CV, copies of all applicable degrees, licenses and certificates.  Transcript copies are accepted but official original required upon hire.  Fax or e-mail of cover letter will not be accepted.  Application address: Virology (Arbovirology) Search Committee, APITMID, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, BSB320, Honolulu, HI 96813. Inquiries: Dr. Duane J. Gubler at 808 956-1600 (dgubler@hawaii.edu) or Dr. Richard Yanagihara at 808 956-1610 (yanagiha@pbrc.hawaii.edu). Continuous recruitment. Review of applications will begin on December 20, 2007 and will continue until the position is filled.

The University of Hawai'i is an equal opportunity/affirmative action institution. All qualified applicants will be considered, regardless of race, sex, age, religion, color, national origin, ancestry, disability, marital status, sexual orientation, or status as disabled veteran or veteran of Vietnam era.

Employment is contingent on satisfying employment eligibility verification requirements of the Immigration Reform and Control Act of 1986. Appointments to positions are subject to campus recruitment guidelines and the collective bargaining agreement.

Ad to be printed on Work@UH and in Science (and other national periodicals)

Assistant or Associate Professor (Virologist), I/M 3-4, position number 82541, John A. Burns School of Medicine (Kaka‘ako Campus), tenure-track, 11-month, 100% full-time, general funds, annually renewable depending on funding and performance, to begin approximately March 2008, pending position clearance and availability of funds.  Departmental appointment will be determined by the candidate’s qualifications; therefore, the candidate may be appointed to a clinical or basic science department. Duties: The Asia-Pacific Institute of Tropical Medicine and Infectious Diseases (APITMID, http://apitmid.hawaii.edu) is seeking a Virologist to establish an independent, transdisciplinary and translational research program of excellence on the pathogenesis of zoonotic viral diseases. The successful applicant will also engage in collaborative studies on microbe-host interactions with other university faculty, and contribute actively to the graduate training and medical education programs, involving traditional lectures and problem-based learning (PBL) tutoring, within the medical school.  Minimum qualifications: Assistant Professor: M.D., M.D./Ph.D., Ph.D., D.V.M., or other doctoral degree in the biosciences with at least three years of postdoctoral research experience and a strong publication record in zoonotic viral diseases, with potential to obtain research funding. Demonstrated ability as a teacher, with good oral and written communication skills.  If M.D., must be board eligible or certified and eligible for Hawaii medical license. Associate Professor: Same as Assistant Professor, with at least four years of experience as an Assistant Professor, research funding from federal or private sources and an active record of publication; proven ability in teaching and recognition for significant scholarly contributions. Desirable qualifications: Research: Demonstrated research experience in cellular and animal models of zoonotic viral diseases, such as avian influenza, and expertise in virus-host interactions and classical and molecular virology. Sustained extramural funding record. Teaching: Experience in PBL pedagogy. Administration: Experience in departmental functions.  Pay range: Commensurate with qualifications and experience.  To apply: Interested candidates should submit a cover letter indicating how they satisfy the minimum and desirable qualifications, official transcripts, names and contact information (including e-mail addresses) of five professional references, current CV, copies of all applicable degrees, licenses and certificates.  Transcript copies are accepted but official original required upon hire.  Fax or e-mail of cover letter will not be accepted. Application address: Virology (Zoonoses) Search Committee, APITMID, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, BSB320, Honolulu, HI 96813. Inquiries: Dr. Duane J. Gubler at 808 956-1600 (dgubler@hawaii.edu) or Dr. Richard Yanagihara at 808 956-1610 (yanagiha@pbrc.hawaii.edu). Continuous recruitment. Review of applications will begin on December 20, 2007 and will continue until the position is filled.

The University of Hawai'i is an equal opportunity/affirmative action institution. All qualified applicants will be considered, regardless of race, sex, age, religion, color, national origin, ancestry, disability, marital status, sexual orientation, or status as disabled veteran or veteran of Vietnam era.

Employment is contingent on satisfying employment eligibility verification requirements of the Immigration Reform and Control Act of 1986. Appointments to positions are subject to campus recruitment guidelines and the collective bargaining agreement.

___________________________________________________________________

Ad to be printed on Work@UH and in Science (and other national periodicals)

Assistant, Associate, or Full Professor (Infectious Disease Pathologist), I/M 3-5, position number 86862, John A. Burns School of Medicine (Kaka‘ako Campus), tenure-track, 11-month, 100% full-time, general funds, annually renewable depending on funding and performance, to begin approximately March 2008, pending position clearance and availability of funds.  Departmental appointment will be determined by the candidate’s qualifications; therefore, the candidate may be appointed to a clinical or basic science department. Duties: The Asia-Pacific Institute of Tropical Medicine and Infectious Diseases (APITMID, http://apitmid.hawaii.edu) is seeking an Infectious Disease Experimental Pathologist to establish an independent, transdisciplinary and translational research program of excellence in animal models of zoonotic and vector-borne diseases.  The successful candidate will also direct the pathology research core facility, supported by the Research Centers in Minority Institutions and the Centers for Biomedical Research Excellence programs, NCRR, NIH.  In addition, the successful applicant will engage in collaborative studies on microbe-host interactions with other university faculty, and contribute actively to the graduate training and medical education programs, involving traditional lectures and problem-based learning (PBL) tutoring, within the medical school. Minimum qualifications: Assistant Professor: M.D., M.D./Ph.D., Ph.D., D.V.M., or other doctoral degree in pathology or experimental pathology, with at least three years of postdoctoral research experience and a strong publication record using animal models of viral diseases, with potential to obtain research funding. Demonstrated ability as a teacher, with good oral and written communication skills.  If M.D., must be board eligible or certified and eligible for Hawaii medical license. Associate Professor: Same as Assistant Professor, with at least four years of experience as an Assistant Professor, research funding from federal or private sources and an active record of publication; proven ability in teaching and recognition for significant scholarly contributions. Full Professor: Same as Associate Professor, with at least four years of experience as an Associate Professor, with a strong record of recent publications and active NIH funding; evidence of excellence in teaching and national or international recognition for research productivity.  Desirable qualifications: Research: Demonstrated research experience in animal and cellular models of vector-borne and zoonotic viral diseases, and expertise in classical and molecular pathology, virus-host interactions and laboratory diagnosis of infectious diseases. Sustained extramural funding record. Teaching: Experience in PBL pedagogy. Administration: Experience in departmental functions.  Pay range: Commensurate with qualifications and experience.  To apply: Interested candidates should submit a cover letter indicating how they satisfy the minimum and desirable qualifications, official transcripts, names and contact information (including e-mail addresses) of five professional references, current CV, copies of all applicable degrees, licenses and certificates.  Transcript copies are accepted but official original required upon hire.  Fax or e-mail of cover letter will not be accepted. Application address: Infectious Disease Pathology Search Committee, APITMID, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, BSB320, Honolulu, HI 96813. Inquiries: Dr. Duane J. Gubler at 808 956-1600 (dgubler@hawaii.edu) or Dr. Richard Yanagihara at 808 956-1610 (yanagiha@pbrc.hawaii.edu). Continuous recruitment. Review of applications will begin on December 20, 2007 and will continue until the position is filled.

 The University of Hawai'i is an equal opportunity/affirmative action institution. All qualified applicants will be considered, regardless of race, sex, age, religion, color, national origin, ancestry, disability, marital status, sexual orientation, or status as disabled veteran or veteran of Vietnam era.

Employment is contingent on satisfying employment eligibility verification requirements of the Immigration Reform and Control Act of 1986. Appointments to positions are subject to campus recruitment guidelines and the collective bargaining agreement.

Ad to be printed on Work@UH and in Science (and other national periodicals)

Assistant or Associate Professor (Medical Entomologist), I/M 3-4, position number xxxx, John A. Burns School of Medicine (Kaka‘ako Campus), tenure-track, 11-month, 100% full-time, general funds, annually renewable depending on funding and performance, to begin approximately July 2008, pending position clearance and availability of funds.  Departmental appointment will be determined by the candidate’s qualifications; therefore, the candidate may be appointed to a clinical or basic science department. Duties: The Asia-Pacific Institute of Tropical Medicine and Infectious Diseases (http://apitmid.hawaii.edu) is seeking a Medical Entomologist to establish an independent, transdisciplinary and translational research program of excellence in vector-borne viral diseases, particularly those caused by flaviviruses, such as West Nile and dengue viruses, and alphaviruses, such as chikungunya and Ross River. The successful applicant will also engage in collaborative studies on microbe-host interactions with other university faculty, and contribute actively to the graduate training and medical education programs, involving traditional lectures and problem-based learning (PBL) tutoring, within the medical school. Minimum qualifications: Assistant Professor: M.D., M.D./Ph.D., Ph.D., D.V.M., or other doctoral degree in the biosciences with at least three years of postdoctoral research experience and a strong publication record in medical entomology, with potential to obtain research funding. Demonstrated ability as a teacher, with good oral and written communication skills.  If M.D., must be board eligible or certified and eligible for Hawaii medical license. Associate Professor: Same as Assistant Professor, with at least four years of experience as an Assistant Professor, research funding from federal or private sources and an active record of publication; proven ability in teaching and recognition for significant scholarly contributions. Desirable qualifications: Research: Demonstrated laboratory and field research experience in vector-borne viral diseases, including virus-vector relationships, vector competence and transmission dynamics, as well as expertise in classical and molecular entomology. Sustained extramural funding record. Teaching: Experience in PBL pedagogy. Administration: Experience in departmental functions.  Pay range: Commensurate with qualifications and experience.  To apply: Interested candidates should submit a cover letter indicating how they satisfy the minimum and desirable qualifications, official transcripts, names and contact information (including e-mail addresses) of five professional references, current CV, copies of all applicable degrees, licenses and certificates.  Transcript copies are accepted but official original required upon hire.  Fax or e-mail of cover letter will not be accepted. Application address: Medical Entomology Search Committee, APITMID, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, BSB320, Honolulu, HI 96813. Inquiries: Dr. Duane J. Gubler at 808 956-1600 (dgubler@hawaii.edu) or Dr. Richard Yanagihara at 808 956-1610 (yanagiha@pbrc.hawaii.edu). Continuous recruitment. Review of applications will begin in February 2008 and will continue until the position is filled.

The University of Hawai'i is an equal opportunity/affirmative action institution. All qualified applicants will be considered, regardless of race, sex, age, religion, color, national origin, ancestry, disability, marital status, sexual orientation, or status as disabled veteran or veteran of Vietnam era.

Employment is contingent on satisfying employment eligibility verification requirements of the Immigration Reform and Control Act of 1986. Appointments to positions are subject to campus recruitment guidelines and the collective bargaining agreement.

___________________________________________________________________

Ad to be printed on Work@UH and in Science (and other national periodicals)

 Assistant or Associate Professor (Immunologist), I/M 3-4, position number xxxx, John A. Burns School of Medicine (Kaka‘ako Campus), tenure-track, 11-month, 100% full-time, general funds, annually renewable depending on funding and performance, to begin approximately July 2008, pending position clearance and availability of funds.  Departmental appointment will be determined by the candidate’s qualifications; therefore, the candidate may be appointed to a clinical or basic science department. Duties: The Asia-Pacific Institute of Tropical Medicine and Infectious Diseases (APITMID, http://apitmid.hawaii.edu) is seeking an Immunologist to establish an independent, transdisciplinary and translational research program of excellence on the immunopathogenesis of vector-borne or zoonotic viral diseases. The successful applicant will also engage in collaborative studies on microbe-host interactions with other university faculty, and contribute actively to the graduate training and medical education programs, involving traditional lectures and problem-based learning (PBL) tutoring, within the medical school. Minimum qualifications: Assistant Professor: M.D., M.D./Ph.D., Ph.D., D.V.M., in immunology, with at least three years of postdoctoral research experience and a strong publication record in viral immunology related to zoonotic and vector-borne diseases, with potential to obtain research funding. Demonstrated ability as a teacher, with good oral and written communication skills.  If M.D., must be board eligible or certified and eligible for Hawaii medical license. Associate Professor: Same as Assistant Professor, with at least four years of experience as an Assistant Professor, research funding from federal or private sources and an active record of publication; proven ability in teaching and recognition for significant scholarly contributions. Desirable qualifications: Research: Demonstrated laboratory research experience in the immunopathogenesis of BSL-2 and BSL-3 viral diseases and expertise in cellular and molecular immunology. Sustained extramural funding record. Teaching: Experience in PBL pedagogy. Administration: Experience in departmental functions.  Pay range: Commensurate with qualifications and experience.  To apply: Interested candidates should submit a cover letter indicating how they satisfy the minimum and desirable qualifications, official transcripts, names and contact information (including e-mail addresses) of five professional references, current CV, copies of all applicable degrees, licenses and certificates.  Transcript copies are accepted but official original required upon hire.  Fax or e-mail of cover letter will not be accepted. Application address: Immunology Search Committee, APITMID, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, BSB320, Honolulu, HI 96813. Inquiries: Dr. Duane J. Gubler at 808 956-1600 (dgubler@hawaii.edu) or Dr. Richard Yanagihara at 808 956-1610 (yanagiha@pbrc.hawaii.edu). Continuous recruitment. Review of applications will begin in February 2008 and will continue until the position is filled.

The University of Hawai'i is an equal opportunity/affirmative action institution. All qualified applicants will be considered, regardless of race, sex, age, religion, color, national origin, ancestry, disability, marital status, sexual orientation, or status as disabled veteran or veteran of Vietnam era.

Employment is contingent on satisfying employment eligibility verification requirements of the Immigration Reform and Control Act of 1986. Appointments to positions are subject to campus recruitment guidelines and the collective bargaining agreement.

Ad to be printed on Work@UH and in Science (and other national periodicals)

Assistant or Associate Professor (Bioinformatician), I/M 3-4, position number xxxx, John A. Burns School of Medicine (Kaka‘ako Campus), tenure-track, 11-month, 100% full-time, general funds, annually renewable depending on funding and performance, to begin approximately July 2008, pending position clearance and availability of funds.  Departmental appointment will be determined by the candidate’s qualifications; therefore, the candidate may be appointed to a clinical or basic science department. Duties: The Asia-Pacific Institute of Tropical Medicine and Infectious Diseases (APITMID, http://apitmid.hawaii.edu) is seeking a Bioinformatician to establish an independent, transdisciplinary and translational research program of excellence in the evolution and ecology of zoonotic and vector-borne infectious diseases. The successful applicant will also engage in collaborative studies on microbe-host interactions with other university faculty, and contribute actively to the graduate training and medical education programs, involving traditional lectures and problem-based learning (PBL) tutoring, within the medical school. Minimum qualifications: Assistant Professor: M.D., M.D./Ph.D., Ph.D., D.V.M., or other doctoral degree in biosciences, with at least three years of postdoctoral research experience and a strong publication record in the evolution and ecology of zoonotic and vector-borne infectious diseases, with potential to obtain research funding. Demonstrated ability as a teacher, with good oral and written communication skills.  If M.D., must be board eligible or certified and eligible for Hawaii medical license. Associate Professor: Same as Assistant Professor, with at least four years of experience as an Assistant Professor, research funding from federal or private sources and an active record of publication; proven ability in teaching and recognition for significant scholarly contributions.  Desirable qualifications: Research: Demonstrated expertise in software program development and microarray analysis. Sustained extramural funding record. Teaching: Experience in PBL pedagogy. Administration: Experience in departmental functions.  Pay range: Commensurate with qualifications and experience.  To apply: Interested candidates should submit a cover letter indicating how they satisfy the minimum and desirable qualifications, official transcripts, names and contact information (including e-mail addresses) of five professional references, current CV, copies of all applicable degrees, licenses and certificates.  Transcript copies are accepted but official original required upon hire.  Fax or e-mail of cover letter will not be accepted. Application address: Bioinformatics Search Committee, APITMID, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, BSB320, Honolulu, HI 96813. Inquiries: Dr. Duane J. Gubler at 808 956-1600 (dgubler@hawaii.edu) or Dr. Richard Yanagihara at 808 956-1610 (yanagiha@pbrc.hawaii.edu). Continuous recruitment. Review of applications will begin in February 2008 and will continue until the position is filled.

 The University of Hawai'i is an equal opportunity/affirmative action institution. All qualified applicants will be considered, regardless of race, sex, age, religion, color, national origin, ancestry, disability, marital status, sexual orientation, or status as disabled veteran or veteran of Vietnam era.

Employment is contingent on satisfying employment eligibility verification requirements of the Immigration Reform and Control Act of 1986. Appointments to positions are subject to campus recruitment guidelines and the collective bargaining agreement.