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NEW APPROACHES FOR FIGHTING EMERGING DISEASES |
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Research Resources |
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Articles in PDF format can be viewed using the free Adobe Acrobat Reader. Articles: WHO Report of the Meeting “Prospects for Malaria Control by Genetic Manipulation of its Vectors” Announcement of the 14 Grand Challenges in Global Health (Science 17 October 2003: Vol. 302. no. 5644, pp. 398 - 399) Ecological Aspects for Application of Genetically Modified Mosquitoes Bridging Laboratory and Field Research for Genetic Control of Disease Vectors Population Dynamics of Transposable Elements: Copy Number Regulation and Species Invasion Requirements (Journal of Biological Systems, Vol. 13, No. 4 (2005) 455-475) Multicountry study of Aedes aegypti pupal productivity survey methodology - Findings and recommendations (TDR/IRM/DEN/06.1) - The objective of this multicountry study was to evaluate the practicality of the survey method and whether it can consistently identify and classify water containers that are particularly productive of the dengue vector, Aedes aegypti. Age and Body Size Influence Male Sperm Capacity of the Dengue Vector Aedes aegypti (Diptera: Culicidae). Alongkot Ponlawat and Laura C. Harrington. Journal of Medical Entomology, Vol. 44, No. 3, May 2007 pp.422-426. January 27-31, 1991 Bugs in the System? Issues in the Science and Regulation of GM Insects (© 2004 Pew Initiative on Food and Biotechnology) outlines the development status of GM insects, the enormous potential benefits of these insects as well as the potential public health, environmental, and food safety risk issues associated with them. The report also examines the regulatory system and points out gaps in authority and areas where transparency, clarity, opportunities for public participation, resources and expertise, efficiency and coordination, or adequate risk management tools could be improved. Guidance for Contained Field Trials of Vector Mosquitoes Engineered to Contain a Gene Driven System: Recommendations of a Scientific Working Group (VECTOR-BORNE AND ZOONOTIC DISEASES, Vol. 8, No. 2, April 2008, pp.127-166) This collaborative effort draws from a wide range of opinions and backgrounds to develop a broad analysis of the issues associated with contained-field testing of genetically engineered arthropod vectors. The guideline is understood to be a “living document,” to serve as the basis for further discussion and to undergo revisions and updates as needed. In that vein, the working group encourages input for further development of the document. Comments and input can be directed to Dr. Stephanie James at containment_guidlines@fnih.org. Reference Locators:
A spreadsheet created by Krisztian Magori that references and summarizes publications on Aedes aegypti can be found here. Items summarized in this spreadsheet include author, year, title, journal, species, location, reference, methods, conclusions, concerns, parameters, and developmental stage analyzed. Literature Retrieval System -- the LRS -Publications can be retrieved from the Armed Forces Pest Management Board, Defense Pest Management Information Analysis Center Tools:
User Friendly Simulation Programs to Model Gene Drive: Several computer models have been created to assist in the analysis of gene drive systems as well as the population dynamics of the mosquito Aedes aegypti. A user manual for these programs gives step-by-step instructions on how to use the models and also includes exercises for exploring the models. These computer model programs are available for free downloading. The site contains computer models for the following gene drive systems: MEDEA; Engineered Underdominance; Meiotic Drive; Homing Endonucleases. Most of the models are deterministic and assume no age or spatial structure. However, one Age Structured Model is included. Additionally, a biologically detailed model of Aedes aegypti population dynamics and gene drive, Skeeter Buster, is also available. (NESCent working group: Selfish DNA and the genetic control of vector-borne database) Aedes aegypti Genome Project- In October 2006, The Institute for Genomic Research (TIGR) merged with several affiliated and legacy organizations - The Center for the Advancement of Genomics (TCAG), The J. Craig Venter Science Foundation, The Joint Technology Center, and the Institute for Biological Energy Alternatives (IBEA)- to form the new J. Craig Venter Institute. e! Ensembl -produces and maintains Aedes aegypti genome annotation Data Base Search tool for Anopheles gambiae Gene Expression Profile at UCI Fitness studies: developing a consensus methodology Vector Base—A Bioinformatics Resource Center for invertebrate Vectors of Human Disease Ano Base—The anopheles database PlasmoDB: The Plasmodium Genome Resource - Release 5.2 -Version 4.4 is still available
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